BIOCHEMISTRY
ENZYMES AND METABOLISM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Allosteric inhibition:The inhibitor binds to the active site of the enzyme
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Competitive inhibition:The maximum rate of a reaction is lowered as the substrate concentration increases
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Non-competitive inhibition:raises the maximum rate of reaction of a given enzyme reaction
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End-product inhibition:The end-product in a metabolic pathway binds to an allosteric site of the first enzyme
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Detailed explanation-1: -When there is an excess of end-product, the whole metabolic pathway is shut down as the end product inhibits the first enzyme of the pathway. Therefore less of the end product gets produced and by inhibiting the first enzyme it also prevents the formation of intermediates.
Detailed explanation-2: -Metabolic pathways refer to the sequence of enzyme catalyzed reactions that lead to the conversion of a substance into a final product. Metabolic cycles encompass a series of reactions in which the substrate is continuously reformed and the intermediate metabolites are continuously regenerated.
Detailed explanation-3: -Feedback inhibition, where the end product of the pathway inhibits an earlier step, is an important regulatory mechanism in cells. The production of both amino acids and nucleotides is controlled through feedback inhibition. For an example of feedback inhibition, consider ATP.
Detailed explanation-4: -The end products are often carbon dioxide, water, and ammonia. Coupled with an endergonic reaction of anabolism, the cell can synthesize new macromolecules using the original precursors of the anabolic pathway.