AP BIOLOGY

BIOCHEMISTRY

ENZYMES AND METABOLISM

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The longest known polypeptide is ____ and contains ____ amino acids.
A
titin; 30, 000
B
aspartame; 3, 000
C
insulin; 300, 000
D
catalase; 3, 000, 000
Explanation: 

Detailed explanation-1: -The largest (longest) single protein known is Titin (connectin: contributing to the passive stiffness of the muscle), which has a molecular size around 30, 000 amino acid residues and three million Da.

Detailed explanation-2: -Titin, is definitely the largest protein in the body, with a molecular weight of 3 million Dalton and composed of 27, 000 amino acids.

Detailed explanation-3: -Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly.

Detailed explanation-4: -Titin is the largest known protein; its human variant consists of 34, 350 amino acids, with the molecular weight of the mature “canonical” isoform of the protein being approximately 3, 816, 030.05 Da. Its mouse homologue is even larger, comprising 35, 213 amino acids with a molecular weight of 3, 906, 487.6 Da.

Detailed explanation-5: -The Dictyostelium discoideum 30, 000-dalton protein is an actin filament-bundling protein that is selectively present in filopodia.

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