AP BIOLOGY

BIOCHEMISTRY

ENZYMES AND METABOLISM

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The mechanism by which the end product of a metabolic pathway inhibits an earlier step in the pathway is called ____
A
metabolic inhibition
B
feedback inhibition
C
irreversible inhibition
D
allosteric regulation
Explanation: 

Detailed explanation-1: -Feedback inhibition, where the end product of the pathway inhibits an earlier step, is an important regulatory mechanism in cells. The production of both amino acids and nucleotides is controlled through feedback inhibition. For an example of feedback inhibition, consider ATP.

Detailed explanation-2: -Final answer: In the feedback inhibition mechanism to control the rate of a metabolic pathway, the end product of the pathway acts as an allosteric inhibitor.

Detailed explanation-3: -Feedback inhibition is a cellular control mechanism in which an enzyme’s activity is inhibited by the enzyme’s end product.

Detailed explanation-4: -Feedback inhibition. Key metabolic enzymes are often inhibited by the end product of the pathway they control (feedback inhibition).

Detailed explanation-5: -Feedback inhibition is usually performed by an “allosteric site” on an enzyme, which alters the shape of enzyme and, as a result, the behaviour of the active site. The end product binding to the allosteric site delays or prevents the enzyme’s activity, resulting in slight or no further end product being produced.

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