AP BIOLOGY

Detailed explanation-1: -The induced-fit model was first proposed by Koshland in 1958 to explain the protein conformational changes in the binding process. This model suggests that an enzyme, when binding with its substrate, optimizes the interface through physical interactions to form the final complex structure.

Detailed explanation-2: -Induced fit Instead, an enzyme changes shape slightly when it binds its substrate, resulting in an even tighter fit. This adjustment of the enzyme to snugly fit the substrate is called induced fit. Illustration of the induced fit model of enzyme catalysis.

Detailed explanation-3: -Many enzymes change shape when substrates bind. This is termed “induced fit", meaning that the precise orientation of the enzyme required for catalytic activity can be induced by the binding of the substrate.

Detailed explanation-4: -There are three different models that represent enzyme-substrate binding: the lock-and-key model, the induced fit model, and transition-state model.

Detailed explanation-5: -The induced-fit model was suggested by Daniel Koshland in 1958. It is the more accepted model for enzyme-substrate complex than the lock-and-key model.