AP BIOLOGY

BIOCHEMISTRY

ENZYMES AND METABOLISM

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Why does enzyme activity decrease when it is in solution that has either a too high or too low pH?
A
All enzymes only work in neutral solutions
B
Enzyme activity remains unchanged in different pH’s
C
The shape of the active site changes
D
The shape of the substrate changes
Explanation: 

Detailed explanation-1: -So, why does pH affect enzyme activity? pH affects enzyme activity because enzymes are proteins that get their molecular structure via interactions between the charges of the amino acids that form the protein chains. These interactions are in the form of a hydrogen bond which is affected by the pH level.

Detailed explanation-2: -Explanation. At very acidic and alkaline pH values the shape of the enzyme is altered so that it is no longer complementary to its specific substrate. This effect can be permanent and irreversible and is called denaturation.

Detailed explanation-3: -Temperature: Raising temperature generally speeds up a reaction, and lowering temperature slows down a reaction. However, extreme high temperatures can cause an enzyme to lose its shape (denature) and stop working. pH: Each enzyme has an optimum pH range. Changing the pH outside of this range will slow enzyme activity.

Detailed explanation-4: -pH is a major factor affecting the activity of enzymes. The ionization of amino acid molecules and atoms occurs when the pH is altered, thereby affecting the structure and form of proteins and hence disrupting their activities.

There is 1 question to complete.