AP BIOLOGY

Detailed explanation-1: -If the enzyme changes shape, the active site may no longer bind to the appropriate substrate and the rate of reaction will decrease. Dramatic changes to the temperature and pH will eventually cause enzymes to denature.

Detailed explanation-2: -The shape of an enzyme is very important because it has a direct effect on how it catalyzes a reaction. An enzyme’s shape is determined by the sequence of amino acids in its structure, and the bonds which form between the atoms of those molecules.

Detailed explanation-3: -Proteins change shape as temperatures change. Because so much of an enzyme’s activity is based on its shape, temperature changes can mess up the process and the enzyme won’t work. High enough temperatures will cause the enzyme to denature and have its structure start to break up.