Body cell Q had a normal mitotic index of 9.3%. However, scientists measured an increase in the mitotic index to 22.7%. This increase could NOT be explained as .....

CELL DIVISION AND CANCEROUS CELLS

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

Body cell ‘Q’ had a normal mitotic index of 9.3%. However, scientists measured an increase in the mitotic index to 22.7%. This increase could NOT be explained as ____

A	a normal increase in cell division due to the cell increasing it’s mitotic rate
B	an abnormal increase in cell division due to mutations in the DNA
C	a normal increase in cell division due to damage/death of nearby cells
D	an abnormal increase in cell division due to the cell ‘blowing through’ its checkpoints

Explanation:

Detailed explanation-1: -An elevated mitotic index indicates more cells are dividing and is an important prognostic factor predicting both overall survival and response to chemotherapy in most cancer types.

Detailed explanation-2: -Durations of the cell cycle and mitosis vary in different cell types. An elevated mitotic index indicates more cells are dividing. In cancer cells, the mitotic index may be elevated compared to normal growth of tissues or cellular repair of the site of an injury.

Detailed explanation-3: -Abstract. Labelling and mitotic indices were studied in the epidermis of twenty-eight young men. A mean labelling index of 5.5% was found from the whole study and a mean mitotic index of 0.06%. Mitotic index particularly was extremely variable; indices between 0.002 and 0.438% were found in individual biopsies.

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