AP BIOLOGY

Detailed explanation-1: -Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a consequence display a radically altered phenotype that is thought to impair tissue function and predispose tissues to disease development and/or progression as they gradually accumulate.

Detailed explanation-2: -Cellular senescence is thought to contribute to age-related tissue and organ dysfunction and various chronic age-related diseases through various mechanisms. In a cell-autonomous manner, senescence acts to deplete the various pools of cycling cells in an organism, including stem and progenitor cells.

Detailed explanation-3: -Senescence literally means “the process of growing old.” It’s defined as the period of gradual decline that follows the development phase in an organism’s life. So senescence in humans would start sometime in your 20s, at the peak of your physical strength, and continue for the rest of your life.

Detailed explanation-4: -(seh-NEH-sents) The process of growing old. In biology, senescence is a process by which a cell ages and permanently stops dividing but does not die. Over time, large numbers of old (or senescent) cells can build up in tissues throughout the body.

Detailed explanation-5: -Cellular senescence is an irreversible cell cycle arrest that is progressive with age. The accumulation of these poorly functional senescent cells results in impaired intercellular communications and compromise tissue function promoting inflammation, consequently induce cell death and loss of cardiomyocytes.