AP BIOLOGY

Detailed explanation-1: -Initiation and completion of DNA replication defines the beginning and ending of S phase of the cell cycle. Successful progression through S phase requires that replication be properly regulated and monitored to ensure that the entire genome is duplicated exactly once, without errors, in a timely fashion.

Detailed explanation-2: -DNA replicates in the S phase of the cell cycle and initiates at specific regions in the DNA sequence known as DNA replication ‘origins’. A number of proteins participate in DNA replication and the process is subject to scrutiny by cell surveillance mechanisms called cell cycle checkpoints.

Detailed explanation-3: -The S phase of the cell cycle occurs before the interphase and is involved in DNA synthesis or replication. In this way, the genetic material of the cell is replicated before entering mitosis or meiosis, leaving enough DNA to divide into daughter cells. S phase is not initiated until the cell passes the G1 phase.

Detailed explanation-4: -S phase is the period of wholesale DNA synthesis during which the cell replicates its genetic content; a normal diploid somatic cell with a 2N complement of DNA at the beginning of S phase acquires a 4N complement of DNA at its end.

Detailed explanation-5: -During the S phase, DNA is duplicated into two sister chromatids, and centrosomes, which give rise to the mitotic spindle, are also replicated. In the G2 phase, energy is replenished, new proteins are synthesized, the cytoskeleton is dismantled, and additional growth occurs.