AP BIOLOGY

CELL DIVISION

CELL DIVISION AND CANCEROUS CELLS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
How is cancer related to the cell cycle?
A
Mutations in the DNA can lead to mutated proteins, which are responsible for regulating the cell cycle
B
Mutations in the DNA can cause all of the affected cells & those around it to become infected & die
C
The cell cycle randomly spirals out of control, causing cancer
D
They’re not related at all
Explanation: 

Detailed explanation-1: -Cancer is the result of unchecked cell division caused by a breakdown of the mechanisms regulating the cell cycle. The loss of control begins with a change in the DNA sequence of a gene that codes for one of the regulatory molecules. Faulty instructions lead to a protein that does not function as it should.

Detailed explanation-2: -Mutations in genes can cause cancer by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death. As a mass of cancerous cells grows, it can develop into a tumor.

Detailed explanation-3: -Sometimes mutations in important genes cause a cell to no longer understand instructions. The cell can start to multiply out of control. It doesn’t repair itself properly, and it doesn’t die when it should. This can lead to cancer.

Detailed explanation-4: -Cell cycle regulators control metabolic enzymes in cancer cells. (A) Highly proliferative cancer cells increase their glycolytic phenotype while reducing oxidative phosphorylation (OXPHOS). Since glycolytic flux is augmented the resulting pyruvate is converted to lactate and secreted extracellularly.

Detailed explanation-5: -Scientists Find a Pair of Proteins Control Supply Lines That Feed Cancer Cells. In human cancer cell and mouse studies, researchers from Johns Hopkins Medicine have found that a set of proteins work in tandem to build supply lines that deliver oxygen and nutrients to tumors, enabling them to survive and grow.

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