CELL DIVISION
CELL DIVISION AND CANCEROUS CELLS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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cell cycle arrest, apoptosis and survival
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DNA repair, cell cycle acceleration and survival
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accelerated cell growth, cell cycle arrest and survival
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accelerated cell growth, increased cell division and survival
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Detailed explanation-1: -The answer is simple: Oncogenes arise as a result of mutations that increase the expression level or activity of a proto-oncogene. Underlying genetic mechanisms associated with oncogene activation include the following: Point mutations, deletions, or insertions that lead to a hyperactive gene product.
Detailed explanation-2: -Oncogenes in their proto-oncogene state drive the cell cycle forward, allowing cells to proceed from one cell cycle stage to the next. This highly regulated process becomes dysregulated due to activating genetic alterations that lead to cellular transformation.
Detailed explanation-3: -Proto-oncogenes encode intracellular regulatory proteins (e.g., protein kinases), growth factors, and growth factor receptors that occupy specific intracellular and cellular membrane sites. All these are important for cell growth and differentiation.
Detailed explanation-4: -To date, most oncogenes have been found to either sensitize cells to cell death, directly cause cell death, or promote growth arrest.