AP BIOLOGY

Detailed explanation-1: -TP53. The p53 protein is involved in DNA damage repair and cell cycle checkpoint control (251). It plays critical roles in maintaining genetic stability, and TP53 is the most commonly mutated tumor suppressor gene in human cancers (251).

Detailed explanation-2: -Genome stability is a feature of every organism to preserve and faithfully transmit the genetic material from generation to generation or from one somatic cell to another.

Detailed explanation-3: -Double-strand breaks in DNA can result in loss and rearrangement of genomic sequences. These breaks are repaired by either nonhomologous end-joining (NHEJ) or by homologous recombination (HR), also called recombinational repair or template–assisted repair.