CELL DIVISION
CELL DIVISION AND CANCEROUS CELLS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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a promoter molecule
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an allosteric inhibitor
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a feedback inhibitor
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a substrate molecule
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Detailed explanation-1: -It inhibits proliferation and induces apoptosis in bcr-abl positive cell lines as well as fresh leukemic cells from Philadelphia chromosome positive chronic myeloid leukemia.
Detailed explanation-2: -Gleevec inhibits (or blocks) specific enzymes in the body called tyrosine kinases. Tyrosine kinase enzymes are involved in many cell functions, including cell signaling (communication), growth, and division. Blocking these enzymes may help to slow cancer growth.
Detailed explanation-3: -Gleevec blocks certain proteins made by the BCR-ABL, PDGFR, or c-KIT oncogene, which may help keep cancer cells from growing and may kill them. Gleevec is a type of tyrosine kinase inhibitor. Also called imatinib mesylate and STI571.
Detailed explanation-4: -We have determined the crystal structure of the complex of imatinib with human NQO2 at 1.75 Å resolution, which reveals that imatinib binds in the enzyme active site, adjacent to the flavin isoalloxazine ring.