CELL DIVISION
CELL DIVISION AND CANCEROUS CELLS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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SMAC will also form a complex that initiates apoptosis
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SMAC inhibits the anti-apoptotic properties of IAP
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SMAC is anti-apoptotic and will bind to Cytochrome-C to reverse the apoptotic process
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Detailed explanation-1: -Cytochrome c (Cyt c) is an essential component of the mitochondrial electron transport chain. It is translated as apocytochrome c and then translocated into the mitochondrial IMS. Once inside the IMS, a heme group is attached to form the holocytochrome c.
Detailed explanation-2: -Under normal conditions, cytochrome c resides into the mitochondria. Exodus of cytochrome c into the cytoplasm induces the non-inflammatory process of apoptosis, whereas once translocated into the extracellular space it may trigger inflammation.
Detailed explanation-3: -The mitochondrial pro-apoptotic protein SMAC/Diablo participates in apoptosis by negatively regulating IAPs and activating caspases, thus encouraging apoptosis.
Detailed explanation-4: -Intrinsic Pathway. The intrinsic signaling pathways that initiate apoptosis involve a diverse array of non-receptor-mediated stimuli that produce intracellular signals that act directly on targets within the cell and are mitochondrial-initiated events.