AP BIOLOGY

Detailed explanation-1: -According to educational materials provided by the National Institutes of Health [2], monoclonal tumor origin means that tumors are derived from a single ancestral cell that underwent conversion from a normal to a cancerous state.

Detailed explanation-2: -The cells of even the most malignant tumours can be formed from normal tissue cells. The determinants of this abnormal behaviour are to be found in the tumour cells themselves, not in their surroundings(5).

Detailed explanation-3: -Abstract. Few ideas have gained such strong acceptance in the scientific community as the monoclonal origin of tumors; the idea that tumors start with a single mutated cell (or a single clone of cells) that go on to accumulate additional mutations as a tumor develops.

Detailed explanation-4: -Monoclonal theory of cancer origin The theory about the monoclonal origin of cancer states that, in general, neoplasms arise from a single cell of origin. While it is possible that certain carcinogens may mutate more than one cell at once, the tumor mass usually represents progeny of a single cell, or very few cells.