The upstream caspases (2, 8, and 10) are called ....., while the downstream caspases (3, 6, and 7) are called ..... (Select all that apply)

CELL DIVISION AND CANCEROUS CELLS

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

The upstream caspases (2, 8, and 10) are called ____, while the downstream caspases (3, 6, and 7) are called ____ (Select all that apply)

A	Initiators; Executioners
B	Initiating caspases; Completing caspases
C	Initiators; Effectors
D	Causers; Effectors

Explanation:

Detailed explanation-1: -Caspase-3 and caspase-7 are both activated universally during apoptosis, irrespective of the specific death-initiating stimulus, and both proteases are widely considered to coordinate the demolition phase of apoptosis by cleaving a diverse array of protein substrates (1, 2).

Detailed explanation-2: -Caspase-9 in mammals and Dronc in Drosophila are initiator caspases, whereas caspases-3 and-7 in mammals and DrICE in Drosophila belong to effector caspases. CED-3 in C. elegans is both the initiator and the effector caspase.

Detailed explanation-3: -Caspase-10 is an initiator caspase in death receptor signaling.

Detailed explanation-4: -The Caspase-Glo® 3/7 Assay(a, b) is a homogeneous, luminescent assay that measures caspase-3 and-7 activities. The assay provides a luminogenic caspase-3/7 substrate, which contains the tetrapeptide sequence DEVD, in a reagent optimized for caspase activity, luciferase activity and cell lysis.

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