AP BIOLOGY

Detailed explanation-1: -The motor symptoms occur predominantly due to substantial dopamine depletion, caused by degeneration of the dopaminergic neurons in substantia nigra pars compacta. Apoptosis has been implicated as the main mechanism of neuronal death in Parkinson’s disease.

Detailed explanation-2: -Too much apoptosis in an otherwise normal human being will result in a number of so-called neurodegenerative diseases where cells die when they’re not supposed to die.

Detailed explanation-3: -Neurodegenerative diseases, such as Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease are all characterized by excessive apoptosis of neurons.

Detailed explanation-4: -The two of the biggest causes of death for people with Parkinson’s are Falls and Pneumonia: Falls – Parkinson’s patients are typically at an increased risk of falls due to postural instability and other symptoms of Parkinson’s.

Detailed explanation-5: -Parkinson’s disease (PD) is a common neurodegenerative disease. Neuronal cell death in PD is still poorly understood, despite a wealth of potential pathogenic mechanisms and pathways. Defects in several cellular systems have been implicated as early triggers that start cells down the road towards neuronal death.