AP BIOLOGY

Detailed explanation-1: -The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood.

Detailed explanation-2: -The p53 gene is a type of tumor suppressor gene. Also called TP53 gene and tumor protein p53 gene.

Detailed explanation-3: -Tumor suppressor genes are normal genes that slow down cell division or tell cells to die at the right time (a process known as apoptosis or programmed cell death). When tumor suppressor genes don’t work properly, cells can grow out of control, which can lead to cancer.

Detailed explanation-4: -A variety of studies carried out with the protein, and later with the gene encoding p53, indicated that it was an oncogene (Eliyahu et al. 1984, Jenkins et al. 1984, Parada et al.

Detailed explanation-5: -The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.