AP BIOLOGY

Detailed explanation-1: -Mitotic spindle, present at the poles of the cells, is a structure made of microtubules (spindle fibres). Its role is to separate the chromosomes. The spindle fibres attach to chromosomes during metaphase and pull the chromatids towards opposite poles during anaphase.

Detailed explanation-2: -The mitotic spindle is a highly dynamic molecular machine composed of tubulin, motors, and other molecules. It assembles around the chromosomes and distributes the duplicated genome to the daughter cells during mitosis.

Detailed explanation-3: -Kinetochore microtubules attach end-on to the kinetochore, which forms at the centromere of each duplicated chromosome. They serve to attach the chromosomes to the spindle. Overlap microtubules interdigitate at the equator of the spindle and are responsible for the symmetrical, bipolar shape of the spindle.

Detailed explanation-4: -The chromosomes are separated by a structure called the mitotic spindle. The mitotic spindle is made of many long proteins called microtubules, which are attached to a chromosome at one end and to the pole of a cell at the other end. The sister chromatids are separated simultaneously at their centromeres.

Detailed explanation-5: -The mitotic spindle is a conserved dynamic macromolecular structure composed of microtubules essential for the alignment and segregation of chromosomes during cell division [1].