CELL DIVISION
CELL DIVISION AND CANCEROUS CELLS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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p53 gene
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cyclins and cyclin-dependent kinases
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thyroid hormones
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Detailed explanation-1: -p53, the Cellular Gatekeeper for Growth and Division: Cell.
Detailed explanation-2: -Summary. Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit-a cyclin-that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra-and intracellular cues.
Detailed explanation-3: -The formation of cyclin/CDKs controls the cell-cycle progression via phosphorylation of the target genes, such as tumor suppressor protein retinoblastoma (Rb). The activation of cyclins/CDKs is induced by mitogenic signals and inhibited by the activation of cell-cycle checkpoints in response to DNA damage [8].
Detailed explanation-4: -Key Points Negative regulator molecules (Rb, p53, and p21) act primarily at the G1 checkpoint and prevent the cell from moving forward to division until damaged DNA is repaired.