AP BIOLOGY

Detailed explanation-1: -Mutations (changes) in the p53 gene may cause cancer cells to grow and spread in the body. These changes have been found in a genetic condition called Li-Fraumeni syndrome and in many types of cancer. The p53 gene is a type of tumor suppressor gene. Also called TP53 gene and tumor protein p53 gene.

Detailed explanation-2: -TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles in development, aging and cell differentiation [2].

Detailed explanation-3: -The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53).

Detailed explanation-4: -The p53 protein, made by the TP53 gene, normally acts as the supervisor in the cell as the body tries to repair damaged DNA.

Detailed explanation-5: -TP53 is a gene that helps stop the growth of tumors. It’s known as a tumor suppressor. A tumor suppressor gene works like the brakes on a car. It puts the “brakes” on cells, so they don’t divide too quickly. If you have a TP53 mutation, the gene may not be able to control the growth of your cells.