CELL DIVISION
CELL DIVISION AND CANCEROUS CELLS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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cyclin binds with MPF to make CDK
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MPF enters the cell through the membrane
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A certain level of MPF allows the cell cycle to continue past the checkpoint
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None of these are true
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Detailed explanation-1: -The G2 checkpoint prevents cells from entering mitosis when DNA is damaged, providing an opportunity for repair and stopping the proliferation of damaged cells. Because the G2 checkpoint helps to maintain genomic stability, it is an important focus in understanding the molecular causes of cancer.
Detailed explanation-2: -At the G2 checkpoint, the cell checks for: DNA damage. DNA replication completeness.
Detailed explanation-3: -The G2-phase checkpoint, also known as G2/M-phase checkpoint, has the function of preventing cells with damaged DNA, lasting from the G1 and S phases or generated in G2, from undergoing mitosis. The mechanisms acting during the G2-phase checkpoint converge on the inhibition of the mitotic complex CDK1-cyclin B.
Detailed explanation-4: -While CDC25A and CDC25B instigate Cyclin B1‐CDK1 activation, CDC25C is responsible for stimulating and maintaining the full‐blown Cyclin B1‐CDK1 activation that ultimately determines to pass the G2 checkpoint 13. It is this role that makes CDC25C an essential node in regulating the decision of the G2 checkpoint.