CELL DIVISION
CELL DIVISION AND CANCEROUS CELLS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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DNA damage to a proto-oncogene, inactive p53 gene, active BRCA1 gene, active telomerase
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DNA damage to a proto-oncogene, active p53 gene, inactive BRCA1 gene, active telomerase
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No DNA damage to a proto-oncogene, inactive p53 gene, inactive BRCA1 gene, active telomerase
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DNA damage to a proto-oncogene, inactive p53 gene, inactive BRCA1 gene, active telomerase
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Detailed explanation-1: -Mutations (changes) in a proto-oncogene may cause it to become an oncogene, which can cause the growth of cancer cells.
Detailed explanation-2: -Different factors are responsible for initiating DNA damage such as radiation and reactive oxygen species which cause several types of lesions in the DNA double helix. The repair pathway involved in the process is dependent on the damaging agent and lesion generated.
Detailed explanation-3: -p53 plays a prominent role as a facilitator of DNA repair by halting the cell cycle to allow time for the repair machineries to restore genome stability. In addition, p53 took on diverse roles to also directly impact the activity of various DNA-repair systems.
Detailed explanation-4: -The most commonly mutated gene in people with cancer is p53 or TP53. More than 50% of cancers involve a missing or damaged p53 gene. Most p53 gene mutations are acquired. Germline p53 mutations are rare, but patients who carry them are at a higher risk of developing many different types of cancer.