AP BIOLOGY

Detailed explanation-1: -Tumor hypoxia develops due to uncontrollable cell proliferation, altered metabolism, and abnormal tumor blood vessels resulting in reduced transport of oxygen and nutrients. Hypoxia is one of the main features of solid tumors and was shown to correlate with poor prognosis of cancer patients.

Detailed explanation-2: -Hypoxia is arguably one of the most attractive therapeutic targets in cancer. Several approaches for targeting hypoxic tumor cells have been proposed, including hypoxia-activated prodrugs, gene therapy and specific targeting of HIFs, or targeting pathways important in hypoxic cells such as mTOR and UPR pathways.

Detailed explanation-3: -Hypoxia is actually divided into four types: hypoxic hypoxia, hypemic hypoxia, stagnant hypoxia, and histotoxic hypoxia. No matter what the cause or type of hypoxia you experience, the symptoms and effects on your flying skills are basically the same.