CELL DIVISION
CELL DIVISION AND CANCEROUS CELLS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Normal checkpoints assess damage to DNA
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Normal checkpoints make sure the cell has enough resources for cell division.
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Normal checkpoints ensure the cells commits apoptosis if the cell has a problem it cannot fix itself.
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Normal checkpoints ignore if there isn’t a strong and sustained signal to divide and divide anyways.
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Detailed explanation-1: -Which statement DOES NOT describe cell cycle checkpoints? Defective checkpoints results in death of the cell. Which statement is not True for DNA? What kind of cells most likely result from uncontrolled growth due to mutations in genes that control the cell cycle?
Detailed explanation-2: -Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis.
Detailed explanation-3: -In normal proliferating cells, initiation of these processes is controlled by genetically-defined pathways known as checkpoints. Tumors often acquire mutations that disable checkpoints and cancer cells can therefore progress unimpeded into S-phase, through G2 and into mitosis with chromosomal DNA damage.
Detailed explanation-4: -The cell cycle is controlled at three checkpoints. The integrity of the DNA is assessed at the G1 checkpoint. Proper chromosome duplication is assessed at the G2 checkpoint. Attachment of each kinetochore to a spindle fiber is assessed at the M checkpoint.