CELL DIVISION
CELL DIVISION AND CANCEROUS CELLS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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It has not grown large enough
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It’s DNA did not replicate properly
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The spindle fibers are not properly attached to the centromere
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Detailed explanation-1: -Explanation: During mitosis, the metaphase checkpoint ensures that each duplicated chromatid is attached to the spindle apparatus. If the metaphase checkpoint is not satisfied, the cell will not enter anaphase.
Detailed explanation-2: -M checkpoint – nuclear division setup check It is also called the spindle checkpoint because the cell examines whether all sister chromatids are correctly attached to the spindle microtubules that separate them. If not, the cell pauses mitosis until all sister chromatids have been attached in the right way.
Detailed explanation-3: -Clearly, kinetochores unattached to spindle microtubules will cause metaphase cell cycle arrest. Without such arrest, anaphase progression would fail to properly segregate chromatids because they lack bipolar spindle attachment.
Detailed explanation-4: -During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores.