CELL DIVISION
MEIOSIS AND GENETIC VARIATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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deletion frameshift
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insertion frameshift
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substitution
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nonsense
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Detailed explanation-1: -Frameshift mutations by insertion or deletion (fsindels) are suggested to induce more immunogenic tumor-specific neoantigens, conferring better response to ICIs. Positive correlation of fsindels with ICI response has been studied in melanoma and renal cell carcinoma.
Detailed explanation-2: -(FRAYM-shift myoo-TAY-shun) An insertion or deletion involving a number of base pairs that is not a multiple of three, which consequently disrupts the triplet reading frame of a DNA sequence.
Detailed explanation-3: -Insertion Mutation Examples For example, some diseases caused by insertional mutations include: Fragile X Syndrome. Huntington’s Disease. Myotonic dystrophy.
Detailed explanation-4: -A frameshift variant occurs when there is an addition or loss of nucleotides that shifts the grouping and changes the code for all downstream amino acids. The resulting protein is usually nonfunctional. Insertions, deletions, and duplications can all be frameshift variants.