AP BIOLOGY

Detailed explanation-1: -The mitotic spindle also begins to develop during prophase. As the cell’s two centrosomes move toward opposite poles, microtubules gradually assemble between them, forming the network that will later pull the duplicated chromosomes apart.

Detailed explanation-2: -In prophase of mitosis, specialized regions on centromeres called kinetochores attach chromosomes to spindle fibers. The centromere is the part of a chromosome that links sister chromatids. During mitosis, spindle fibers attach to the centromere via the kinetochore.

Detailed explanation-3: -The mitotic spindle begins to self-assemble in the cytoplasm during prophase. In animal cells, each of the replicated centrosomes nucleates its own array of microtubules, and the two sets of microtubules interact to form the mitotic spindle.

Detailed explanation-4: -During prophase, the complex of DNA and proteins contained in the nucleus, known as chromatin, condenses. The chromatin coils and becomes increasingly compact, resulting in the formation of visible chromosomes.

Detailed explanation-5: -Chromosomes attach to spindle fibers during metaphase. Chromosomes contain a cell’s DNA or genetic information. Before entering mitosis, the cell duplicates its DNA during the synthesis stage of the cell cycle. This DNA must be split in order to place one of each copy into two separate cells.