CELL DIVISION
THE CELL CYCLE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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They undergo apoptosis.
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They do not respond to growth inhibitors
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They respond to growth inhibitors.
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Detailed explanation-1: -Insensitivity to growth-inhibitory (antigrowth) signals: cancer cells inactivate tumor suppressor genes, such as Rb, that normally inhibit growth.
Detailed explanation-2: -Cancer cells are often very sensitive to growth factors. So if we can block them, we can stop some types of cancer from growing and dividing. Scientists are developing different inhibitors for the different types of growth factors.
Detailed explanation-3: -Cancer cells do not exhibit contact inhibition. While most cells can tell if they are being ‘crowded’ by nearby cells, cancer cells no longer respond to this stop signal.
Detailed explanation-4: -In contrast to normal cells, cancer cells don’t stop growing and dividing, this uncontrolled cell growth results in the formation of a tumor. Cancer cells have more genetic changes compared to normal cells, however not all changes cause cancer, they may be a result of it.
Detailed explanation-5: -Hence, the property which cancer cells does not have is they show contact inhibition.