AP BIOLOGY

Detailed explanation-1: -It is well known that the activation of glycolysis produces H+ in the cytosol. Therefore, cells would come back from aerobic glycolysis to oxphos when the activation of glycolysis would lead to a concentration of H+ high enough to reverse the intracellular alkalinization.

Detailed explanation-2: -For glycolysis, the conversion of glucose to lactate-+ H+ and the export of products into the assay medium is the source of glycolytic acidification. For respiration, the export of CO2, hydration to H2CO3 and dissociation to HCO3-+ H+ is the source of respiratory acidification.

Detailed explanation-3: -Stimulation of glycolysis accompanies a rise in pH in intact polymorphonuclear leukocytes and supernatant preparations derived from homogenates of these cells. The curve of lactate production plotted against pH for the cell-free system was steepest between pH 6.5 and 7.0.

Detailed explanation-4: -During postmortem glycolysis, skeletal muscle mobilizes stored carbohydrate known as glycogen into ATP, lactate, and ultimately H+ ions. The formation of H+ ions result in a drop in the muscle pH from 7.2 in living muscle to a pH near 5.5 in meat under normal conditions (Scheffler et al., 2011).

Detailed explanation-5: -Aerobic Glycolysis May Increase pHc via NHE1 Activation Several reports have shown that glucose stimulation of cells is sufficient to increase pHc in an NHE1-dependent manner.