CELL RESPIRATION
THE KREBS CYCLE
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Detailed explanation-1: -Pyruvate-three carbons-is converted to acetyl CoA, a two-carbon molecule attached to coenzyme A .
Detailed explanation-2: -Pyruvate oxidation produces acetyl Coenzyme A, NADH, and carbon dioxide.
Detailed explanation-3: -Key Points. In the conversion of pyruvate to acetyl CoA, each pyruvate molecule loses one carbon atom with the release of carbon dioxide. During the breakdown of pyruvate, electrons are transferred to NAD+ to produce NADH, which will be used by the cell to produce ATP.
Detailed explanation-4: -Note that this process completely oxidizes 1 molecule of pyruvate, a 3 carbon organic acid, to 3 molecules of CO2. During this process, 4 molecules of NADH, 1 molecule of FADH2, and 1 molecule of GTP (or ATP) are produced.
Detailed explanation-5: -The resulting compound is called acetyl CoA. CoA is made from vitamin B5, pantothenic acid. Acetyl CoA can be used in a variety of ways by the cell, but its major function is to deliver the acetyl group derived from pyruvate to the next stage of the pathway in glucose catabolism.