CELL RESPIRATION
THE KREBS CYCLE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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cytosol outside the mitochondrion
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the intermembrane space of the mitochondrion
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in the mitochondrial matrix
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the outer membrane of the mitochondrion
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Detailed explanation-1: -Pyruvate is produced by glycolysis in the cytoplasm, but pyruvate oxidation takes place in the mitochondrial matrix (in eukaryotes). So, before the chemical reactions can begin, pyruvate must enter the mitochondrion, crossing its inner membrane and arriving at the matrix.
Detailed explanation-2: -Oxidation of Pyruvate Occurs During the Transition Reaction Once in the intermembrane space, the three-carbon pyruvate will be transformed into a two-carbon acetyl group and one molecule of CO2 gas which will diffuse back out into the body.
Detailed explanation-3: -Pyruvate crosses the outer mitochondrial membrane (OMM) probably via the VDAC into the intermembrane space (IMS). Pyruvate is then transported across the IMM by the MPC. It has also been suggested that the MPC transports ketone bodies across the IMM.
Detailed explanation-4: -After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
Detailed explanation-5: -Aerobic oxidation of pyruvic acid takes place in the Mitochondria of the cell.