CELL RESPIRATION
THE KREBS CYCLE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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True
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False
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Detailed explanation-1: -In normal condition, acetyl-CoA is mainly channeled into the Krebs cycle for energy production. In overnutrition state, acetyl-CoA can be used to store excess energy by forming fatty acids. Acetyl-CoA is also the source for cholesterol synthesis. In starved state, acetyl-CoA is converted into ketone bodies.
Detailed explanation-2: -Acetyl-CoA carboxylases 1 and 2 (ACC1 and ACC2) catalyze the synthesis of malonyl-CoA, the substrate for fatty acid synthesis and the regulator of fatty acid oxidation. They are highly regulated and play important roles in the energy metabolism of fatty acids in animals, including humans.
Detailed explanation-3: -When excess acetyl CoA is produced that cannot be processed through the Krebs cycle, the acetyl CoA is converted into triglycerides and fatty acids to be stored in the liver and adipose tissue. If diabetes is uncontrolled, the glucose in the blood is not being taken up and processed by the cells.
Detailed explanation-4: -Acetyl-CoA (acetyl coenzyme A) is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism. Its main function is to deliver the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production.