AP BIOLOGY

Detailed explanation-1: -Antimicrobial resistance happens when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. That means the germs are not killed and continue to grow. Resistant infections can be difficult, and sometimes impossible, to treat.

Detailed explanation-2: -Bacteria that are resistant to many antibiotics are known as multi-resistant organisms (MRO). Antibiotic resistance is a serious public health problem.

Detailed explanation-3: -Germs get rid of antibiotics using pumps in their cell walls to remove antibiotic drugs that enter the cell. Example: Some Pseudomonas aeruginosa bacteria can produce pumps to get rid of several different important antibiotic drugs, including fluoroquinolones, beta-lactams, chloramphenicol, and trimethoprim.

Detailed explanation-4: -Antimicrobial resistance mechanisms fall into four main categories: (1) limiting uptake of a drug; (2) modifying a drug target; (3) inactivating a drug; (4) active drug efflux.