EVOLUTION
SOURCES OF VARIATION IN A POPULATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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mutations
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mutagens
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meiosis
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genetic mutations
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Detailed explanation-1: -Heavy metals such as cadmium, arsenic and nickel are classified as carcinogens. Although the precise mechanism of carcinogenesis is undefined, heavy metal exposure can contribute to genetic damage by inducing double strand breaks (DSBs) as well as inhibiting critical proteins from different DNA repair pathways.
Detailed explanation-2: -Nucleotide excision repair is another pathway used to remove and replace damaged bases. Nucleotide excision repair detects and corrects types of damage that distort the DNA double helix.
Detailed explanation-3: -When Replication Errors Become Mutations. Incorrectly paired nucleotides that still remain following mismatch repair become permanent mutations after the next cell division. This is because once such mistakes are established, the cell no longer recognizes them as errors.
Detailed explanation-4: -High-dose heavy metals exposure, particularly mercury and lead, may induce severe complications such as abdominal colic pain, bloody diarrhea, and kidney failure (Bernhoft, 2012; Tsai et al., 2017).