AP BIOLOGY

Detailed explanation-1: -Missense Mutation A missense mutation is a DNA change that results in different amino acids being encoded at a particular position in the resulting protein. Some missense mutations alter the function of the resulting protein.

Detailed explanation-2: -Answer and Explanation: The correct answer is D) The substrate would no longer fit in the active site, so the enzyme specificity is lost.

Detailed explanation-3: -Amino acid replacement is a change from one amino acid to a different amino acid in a protein due to point mutation in the corresponding DNA sequence. It is caused by nonsynonymous missense mutation which changes the codon sequence to code other amino acid instead of the original.

Detailed explanation-4: -A mutation that occurs in a section of DNA that codes for an amino acid sequence found in an enzyme’s active site can modify the folded shapes of the active site and its affinity for its substrate.