AP BIOLOGY

Detailed explanation-1: -Missense: A missense variant is a type of substitution in which the nucleotide change results in the replacement of one protein building block (amino acid) with another in the protein made from the gene. The amino acid change may alter the function of the protein.

Detailed explanation-2: -(MIS-sens myoo-TAY-shun) A genetic alteration in which a single base pair substitution alters the genetic code in a way that produces an amino acid that is different from the usual amino acid at that position. Some missense variants (or mutations) will alter the function of the protein. Also called missense variant.

Detailed explanation-3: -A missense mutation is a mistake in the DNA that results in the integration of an undesirable amino acid into a protein as a result of changing a single nucleotide in the DNA. The finest example of a missense alteration is a pallor known as sickle cell anaemia.

Detailed explanation-4: -Substitution mutation is sometimes referred to as point mutation. However, point mutation is defined particularly as a type of mutation involving a change of only one nucleotide. See also: transversion. transition.

Detailed explanation-5: -A point mutation is where you change one base in the DNA to another. A missense mutation occurs when that point mutation causes a different amino acid to be placed from that codon. Because multiple codons code for the same amino acid, not all point mutations will cause a missense mutation.