HEREDITY
MUTATIONS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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substitution of T for the first A in the sequence
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deletion of GTT from the sequence
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insertion of C at the start of the sequence
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substitution of ATA for ACG in the sequence
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Detailed explanation-1: -A frameshift variant occurs when there is an addition or loss of nucleotides that shifts the grouping and changes the code for all downstream amino acids. The resulting protein is usually nonfunctional. Insertions, deletions, and duplications can all be frameshift variants.
Detailed explanation-2: -During transcription, if the nucleotide sequence of the DNA strand that is being coded is ATACG, then the nucleotide sequence in the mRNA would be UAUGC because in RNA, the bases are adenine (A), cytosine (C), guanine (G), or uracil (U).
Detailed explanation-3: -Frameshift mutations arise when the normal sequence of codons is disrupted by the insertion or deletion of one or more nucleotides, provided that the number of nucleotides added or removed is not a multiple of three.
Detailed explanation-4: -Frameshift mutations can occur either by deleting or inserting the nucleotide in the nucleic acid (Figure 3). Deletion frameshift mutation, wherein one or more nucleotides are deleted in a nucleic acid, resulting in the alteration of the reading frame, i.e., reading frameshift, of the nucleic acid.