AP BIOLOGY

HEREDITY

MUTATIONS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Early-onset Alzheimer’s disease affects people under the age of 65. Less than five percent of people who are diagnosed with Alzheimer’s disease have this type. Many cases of early-onset Alzheimer’s disease are inherited, a type known as familial Alzheimer’s disease (FAD). Which statement is best supported by this information?
A
FAD is the result of a genetic change in one or more chromosomes
B
Natural selection will continue to reduce the incidence of FAD
C
FAD affects only the genes of middle-aged people
D
Deletion of one amino acid causes FAD
Explanation: 

Detailed explanation-1: -Early-onset Alzheimer’s disease is rare, representing less than 10 percent of all people with Alzheimer’s. It typically occurs between a person’s 30s and mid-60s. Some cases are caused by an inherited change in one of three genes.

Detailed explanation-2: -Alzheimer’s disease is the most common type of dementia. Current estimates are that about 5.8 million people in the United States have Alzheimer’s disease and related dementias, including 5.6 million aged 65 and older and about 200, 000 under age 65 with younger-onset Alzheimer’s.

Detailed explanation-3: -When Alzheimer disease occurs in someone under age 65, it is known as early-onset (or younger-onset) Alzheimer disease. A very small number of people with Alzheimer disease have the early-onset form. Many of them are in their 40s and 50s when the disease takes hold.

Detailed explanation-4: -Memory problems are typically one of the first signs of the disease. Decline in non-memory aspects of cognition, such as finding the right word, trouble understanding visual images and spatial relationships, and impaired reasoning or judgment, may also signal the early stages of Alzheimer’s.

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