HEREDITY
MUTATIONS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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duplication
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translocation
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inversion
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Detailed explanation-1: -Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia.
Detailed explanation-2: -Several chromosomal abnormalities such as monosomies or deletions of part or all of chromosomes 5 or 7 (–5/–7 AML) and trisomy 8 are common in AML.
Detailed explanation-3: -Causes. Chronic myeloid leukemia is caused by a rearrangement (translocation ) of genetic material between chromosome 9 and chromosome 22. This translocation, written as t(9; 22), fuses part of the ABL1 gene from chromosome 9 with part of the BCR gene from chromosome 22, creating an abnormal fusion gene called BCR-ABL1.
Detailed explanation-4: -Chromosome 16 inversion is one of the most common chromosome abnormalities in human acute myeloid leukemia. A fusion gene between the core binding factor B (CBFB) gene and the myosin heavy chain 11 (MYH11) gene is generated by this inversion.