AP BIOLOGY

Detailed explanation-1: -If the enzyme changes shape, the active site may no longer bind to the appropriate substrate and the rate of reaction will decrease. Dramatic changes to the temperature and pH will eventually cause enzymes to denature.

Detailed explanation-2: -The shape of the active site will change irreversibly, and it will no longer be able to bind to its substrate. The enzyme is said to be denatured, or we say that denaturation has occurred.

Detailed explanation-3: -As a substrate binds to the active site, the active site changes shape a little, grasping the substrate more tightly and preparing to catalyze the reaction. After the reaction takes place, the products are released from the active site and diffuse away.

Detailed explanation-4: -What might happen to an enzyme’s activity if a mutation caused a change to the shape of the active site. If the change affects the active site of the enzyme, the activity of the enzyme then would be affected. The change would cause the reaction rate to go down.

Detailed explanation-5: -However, extreme high temperatures can cause an enzyme to lose its shape (denature) and stop working. pH: Each enzyme has an optimum pH range. Changing the pH outside of this range will slow enzyme activity. Extreme pH values can cause enzymes to denature.