AP BIOLOGY

Detailed explanation-1: -(MIS-sens myoo-TAY-shun) A genetic alteration in which a single base pair substitution alters the genetic code in a way that produces an amino acid that is different from the usual amino acid at that position. Some missense variants (or mutations) will alter the function of the protein.

Detailed explanation-2: -Substitution mutations just switch out one or more bases for different ones. Substitution mutations can cause many kinds of mutations. Some of these include nonsense, missense, and silent mutations. All of these depend on whether or not the new base codes for an amino acid different than the original.

Detailed explanation-3: -Missense mutations occur when a single nucleotide base in a DNA sequence is swapped for another one, resulting in a different codon and, therefore, a different amino acid. These mutations are quite common and, in most cases, they don’t affect the overall shape and function of the protein.

Detailed explanation-4: -Missense: A missense variant is a type of substitution in which the nucleotide change results in the replacement of one protein building block (amino acid) with another in the protein made from the gene. The amino acid change may alter the function of the protein.