HEREDITY
NONDISJUNCTION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Klinefelter Syndrome
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Down Syndrome
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Turner’s Syndrome
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Hurler Syndrome
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Detailed explanation-1: -Mucopolysarcharidosis type I (MPS I) is a rare, inherited disorder. MPS I is also known as Hurler syndrome. Children with Hurler syndrome have an abnormal accumulation of complex sugars in their cells, which affects many of the systems in their bodies.
Detailed explanation-2: -MPS I is subdivided into three subtypes: Hurler syndrome (severe), Hurler-Scheie syndrome (intermediate), and Sheie syndrome (mild). Diagnosis of this condition is based on a thorough clinical examination, and measurement of urinary GAG levels is a useful screening test.
Detailed explanation-3: -History. In 1919, Gertrud Hurler, a German pediatrician, described a syndrome involving corneal clouding, skeletal abnormalities, and mental retardation. A similar disease of “gargoylism” had been described in 1917 by Charles A. Hunter.