AP BIOLOGY

Detailed explanation-1: -Acetyl CoA is generated by oxidative decarboxylation of pyruvate, the end-product of glycolysis. The oxidative decarboxylation of pyruvate occurs in mitochondrial matrix.

Detailed explanation-2: -So the correct option is ‘Mitochondrial matrix’.

Detailed explanation-3: -During cellular respiration acetyl CoA accumulates in the mitochondrial matrix. It is produced by the multiprotein complex known as pyruvate dehydrogenase. This molecule synthesizes acetyl CoA using pyruvate which would have entered the mitochondria from the cytoplasm.

Detailed explanation-4: -Acetyl-CoA is produced in the mitochondrial matrix by oxidative decarboxylation of pyruvate from glycolysis, oxidation of long-chain fatty acids, or oxidative degradation of specific amino acids. The acetyl-CoA is then oxidised for energy production in the TCA cycle.

Detailed explanation-5: -There are three main steps of cellular respiration: glycolysis, the citric acid cycle, and oxidative phosphorylation. Glycolysis takes place in the cytosol, the citric acid cycle occurs in the mitochondrial matrix, and oxidative phosphorylation occurs on the inner mitochondrial membrane.