LABORATORY REVIEW
MITOSIS AND MEIOSIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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So that another round of DNA synthesis does not have to take place.
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So that the chromosomes can align at the metaphase plate during mitosis.
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So that the cytoplasm can be divided equally between the two daughter cells.
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So that healthy daughter cells are produced, allowing the organism to continue growing.
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Detailed explanation-1: -Cells pass through a G2 checkpoint before entering mitosis. Ideally, if DNA damage is detected, the cells do not enter mitosis until the damage is repaired. Why is DNA damage repaired before cells enter mitosis? So that healthy daughter cells are produced, allowing the organism to continue to grow.
Detailed explanation-2: -The G2/M checkpoint prevents cells from entering mitosis when DNA is damaged in order to afford these cells an opportunity to repair the damaged DNA before propagating genetic defects to the daughter cells. If the damage is irreparable, checkpoint signaling might activate pathways that lead to apoptosis.
Detailed explanation-3: -WEE1 arrests cells in the G2 phase of the cell cycle, allowing cells to repair DNA before proceeding into mitosis. After de Schutter et al.
Detailed explanation-4: -The G1/S and G2/M checkpoints are initiated in response to DNA damage to prevent the transmission of damaged or incomplete chromosomes to daughter cells. The DNA-damage checkpoints provide cells with time to repair damaged DNA.
Detailed explanation-5: -The cells possessing a defective G2-M checkpoint to enter the M phase prior to DNA being repaired, it generally leads to death post the cell division or apoptosis.