LABORATORY REVIEW
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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(a) DDBJ
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(b) PDB
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( c) EMBL
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d) TRANSFAC
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Detailed explanation-1: -TRANSFAC is a database about eukaryotic transcription regulating DNA sequence elements and the transcription factors binding to and acting through them.
Detailed explanation-2: -GTRD-Gene Transcription Regulation Database (http://gtrd.biouml.org)-is a database of transcription factor binding sites (TFBSs) identified by ChIP-seq experiments for human and mouse.
Detailed explanation-3: -A TF is a protein that can bind to DNA and regulate gene expression. The region of the gene to which TF binds is called a transcription factor binding site.
Detailed explanation-4: -TRANSFAC is a manually curated database for eukaryotic TFs and their genomic binding sites (Wingender et al., 2000). It is an encyclopedia for transcriptional regulation and is an apt tool for extensive genomic analysis to predict potential transcription factor binding sites (TFBSs).
Detailed explanation-5: -Transcription factors are proteins that help turn specific genes “on” or “off” by binding to nearby DNA.