LABORATORY REVIEW
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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the addition of lysine to histone tails, allowing transcription to occur.
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the increased translation rate of a gene.
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the addition of an acetyl group to the tail of a histone protein which packs the DNA tighter, not allowing the expression of the genes.
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the addition of an acetyl group to the tail of a histone protein which unpacks the DNA, allowing the genes to be expressed.
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Detailed explanation-1: -The addition of the acetyl group neutralizes this positive charge and hence reduces the binding between histones and DNA, leading to a more open structure which is more accessible to the transcriptional machinery. Histone acetylation therefore leads to transcriptional activation.
Detailed explanation-2: -Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cycle progression and differentiation.
Detailed explanation-3: -Histone acetyltransferase (HATs) Histone Acetyltransferases, also known as HATs, are a family of enzymes that acetylate the histone tails of the nucleosome.
Detailed explanation-4: -Histone acetylation occurs at lysine residues and it increases gene expression in general.