AP BIOLOGY

Detailed explanation-1: -Craig Venter and colleagues published, in May 1995, the first completely sequenced genome of a self-replicating, free-living organism-the bacteria Haemophilus influenzae Rd. A circular representation of the H. influenzae Rd genome.

Detailed explanation-2: -The Institute for Genomic Research sequenced the first complete genome, that of the bacterium Haemophilus influenzae. A few months later, researchers there finished sequencing the smallest known genome, that of the bacterium Mycoplasma genitalium.

Detailed explanation-3: -1977. Frederick Sanger develops a DNA sequencing technique which he and his team” use to sequence the first full genome – that of a virus called phiX174.

Detailed explanation-4: -The first bacterium to be sequenced was Haemophilus influenzae [40], and this was done by the shotgun method developed by Sanger et al.

Detailed explanation-5: -Genome. The genome of Haemophilus influenzae (Rd KW20) was sequenced first among the members of Pasteurellaceae family (Fleischmann et al., 1995). P. multocida genome is 1.4–2.4 Mbp in size with GC content 37–41 mol%.