LABORATORY REVIEW
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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a polypeptide missing an amino acid.
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a base-pair substitution.
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a frameshift mutation.
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a nucleotide mismatch.
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Detailed explanation-1: -The most commonly occurring mutation in people with cystic fibrasis is a deletion of a single codon: What is the result of this type of mutation? a frameshift mutatlon polypeptide missing Its N-terminus polypeptide missing an amino acid base-pair substitution.
Detailed explanation-2: -The most common CF mutation, F508del, is primarily considered to be a processing mutation. The F508del mutation removes a single amino acid from the CFTR protein.
Detailed explanation-3: -The delta F508 is the most common defect in the cystic fibrosis (CF) gene; it involves in a 3-base deletion in codon 508 and results in the loss of a phenylalanine residue at amino acid position 508.
Detailed explanation-4: -A mutation known to occur in cystic fibrosis is the deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR). The amino acid is in the first nucleotide-binding domain (NBD) of CFTR.
Detailed explanation-5: -Point mutations are the most common type of mutation and there are two types.