AP BIOLOGY

Detailed explanation-1: -The wobble position of a codon refers to the 3rd nucleotide in a codon. This nucleotide has two major characteristics: Binding of a codon in an mRNA the cognate tRNA is much “looser” in the third position of the codon. This permits several types of non-Watson–Crick base pairing to occur at the third codon position.

Detailed explanation-2: -Wobble pairing follows its own set of rules: for example, while G in an anticodon can pair with C or U at the third position of a codon, it cannot pair with A or G. This ensures codons are read correctly despite wobble pairing.

Detailed explanation-3: -The relaxed base-pairing requirement, or “wobble, ” allows the anticodon of a single form of tRNA to pair with more than one triplet in mRNA. The rules: first base U can recognize A or G, first base G can recognize U or C, and first base I can recognize U, C or A.

Detailed explanation-4: -The anticodon loops of almost all tRNAs contain several modified nucleotides. Among these, the most important are nucleotides in the positions 34 and 37. The nucleotide in position 34 (so-called ‘wobble’ position) pairs with the third mRNA codon base in the aminoacyl-tRNA binding site (A-site) during decoding4, 8.